Morphological types of hepatocellular hyalin in Indian childhood cirrhosis: an ultrastructural study.
نویسندگان
چکیده
Morphological variants of intrahepatocytic hyalin in Indian childhood cirrhosis have been analysed by electron microscopy. This structure, morphologically identical with Mallory's alcoholic hyalin, is encountered in three different forms. The most common one is composed of randomly oriented fibrils. The next common type is composed of smudgy homogeneous or finely granular material, while the least common type consists of parallel fibrils with gentle curves giving a 'finger-print' appearance. Fragmented endoplasmic reticulum and ribosomes were frequently associated with hyalin suggesting that these organelles contribute to their formation.
منابع مشابه
An ultrastructural study of the liver in Indian childhood cirrhosis with particular reference to the structure of cytoplasmic hyaline.
Ultrastructural features of the liver in eight cases of Indian childhood cirrhosis, a fatal and elusive liver disease in India, have been described. Severe parenchymal damage, diffuse creeping fibrosis, and other light microscopic alterations, including the frequent presence of cytoplasmic hyaline, reported earlier are confirmed in the present study. The hyaline is predominantly comprised of ta...
متن کاملIndian Childhood Cirrhosis: Case Report and Pediatric Diagnostic Challenges
Introduction: Indian childhood cirrhosis is a chronic liver disease usually seen in paediatric age group and is unique to the Indian subcontinent. The definitive causative factor for the disease is not found till now but excess copper ingestion has been associated with it.Case presentation: An Indian origin one and half year old premorbidly normal male child presented with history of gradual di...
متن کاملComparison of hepatitis C virus risk factors in genotypes 1a and 3a
Background: One of the most important causes of chronic liver disease is hepatitis C virus (HCV), which causes liver cirrhosis and hepatocellular carcinoma. To control the prevalence of the disease, knowledge and information in risk factor of HCV are required. The aim of this study was to compare the risk factors of infection between HCV patients with genotypes 1a and 3a. Methods: This is an o...
متن کاملCombined use of alcohol in conventional chemical-induced mouse liver cancer model improves the simulation of clinical characteristics of human hepatocellular carcinoma
Liver cancer is the one of most common types of cancer and the 2nd cause of cancer-associated mortalities worldwide. Establishing appropriate animal models of liver cancer is essential for basic and translational studies. The present study evaluated the effects of the combined use of alcohol with a conventional chemical-induced mouse liver cancer model. The treatment of alcohol/diethylnitrosami...
متن کاملEvaluation of serum AFP (α-fetoprotein) level in HBsAg carrier patients for diagnosis of hepatocellular carcinoma
Background: Hepatocellular carcinoma (HCC) is common all over the world as well as Iran. The incidence of HCC is higher in hepatitis B carriers and it is highly recommended to periodically screen these patients by serum alpha-fetoprotein (AFP) and liver ultrasound (US) every 6 months. We explore the diagnostic accuracy and the performance of (AFP) in cases of hepatitis B carriers as a scree...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Gut
دوره 17 10 شماره
صفحات -
تاریخ انتشار 1976